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目的观察针灸联合利培酮治疗脑卒中后幻觉症的临床效果。方法将98例脑卒中后幻觉症患者随机分为两组,每组49例。对照组口服利培酮片治疗,治疗组给予针灸联合口服利培酮片治疗,疗程3周。结果治疗组总有效率为97.96%,对照组为87.76%;治疗组临床疗效明显优于对照组(P<0.05)。治疗后两组躯体化等生活质量评分较治疗前有所降低(P<0.05,P<0.01),且治疗组低于对照组(P<0.05)。治疗后两组患者认知记忆能力评分均较治疗前显著增加(P<0.05),且治疗组评分高于对照组(P<0.05)。治疗后两组患者血浆5-HT含量明显增加(P<0.05),且治疗组血浆5-HT含量明显高于对照组(P<0.05)。结论针灸联合利培酮片治疗脑卒中后幻觉症能改善患者临床症状、提高生活质量,其机制可能与促进血浆5-HT释放有关。
Objective To observe the clinical effect of acupuncture combined with risperidone on post-stroke hallucination. Methods 98 cases of post-stroke hallucination patients were randomly divided into two groups, 49 cases in each group. Control group oral risperidone tablets treatment, the treatment group given acupuncture combined with oral risperidone tablets for 3 weeks. Results The total effective rate was 97.96% in the treatment group and 87.76% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group (P <0.05). After treatment, the scores of somatization quality of life in the two groups were lower than before treatment (P <0.05, P <0.01), and the treatment group was lower than the control group (P <0.05). After treatment, the scores of cognitive memory in both groups were significantly increased (P <0.05), and the score of the treatment group was higher than that of the control group (P <0.05). After treatment, the plasma 5-HT content of both groups increased significantly (P <0.05), and the content of 5-HT in the treatment group was significantly higher than that of the control group (P <0.05). Conclusion Acupuncture combined with risperidone tablets in the treatment of post-stroke hallucinations can improve the clinical symptoms and improve the quality of life, and its mechanism may be related to the promotion of plasma 5-HT release.