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Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water.The analgesic effect of extracts of P.eous were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip tests.Results:P.eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P<0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P<0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P<0.05).Conclusions:The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs.
Objective: To evaluate the analgesic activity of the ethyl acetate, methanol and aqueous extracts of Plewotus eous (P.eous) mushroom. Methods: The dried fruiting bodies were extracted with ethyl acetate, methanol and water. The analgesic effect of extracts of P. eous were investigated at doses 250 500 and 1 000 mg / kg body weight, using acetic-acid induced writhing, hot-plate, tail immersion and tail-clip tests. Results: P.eous extracts produced significant reduction in number of writhes induced by Coreover, in hot-plate and tail immersion test, all the three extracts significantly raised the pain threshold at different time of observation (0-60 min) in comparison with control (P <0.05) 0.05). In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used (P <0.05). Conclusions: The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs.