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目的研究冠心病经皮冠脉介入治疗(PCI)者N末端脑钠肽前体(NT-proBNP)水平与冠脉病变严重程度是否相关,探讨NT-proBNP作为冠心病疾病严重程度客观生化指标的临床意义。方法顺序入选因冠心病行冠状动脉造影且行NT-proBNP检测的患者844例,按照冠状动脉狭窄Gensini积分、不同冠状动脉病变和不同梗死相关血管进行分组,采用方差分析和2χ检验等分析对比各组间NT-proBNP水平和心功能相关指标的差异。结果随着病变支数的增加,NT-proBNP水平升高,左房直径增大,左室射血分数(LVEF)减低;随着Gensini积分的增加,NT-proBNP水平、患者年龄和左室舒张末径(LVEDd)升高,LVEF降低,差异均有统计学意义(P<0.05)。NT-proBNP与年龄、左房直径、LVEDd、Gensini积分、病变支数呈正相关,与LVEF呈负相关(P<0.01)。结论冠心病患者NT-proBNP水平与疾病的严重程度有一定的相关性,NT-proBNP可能会成为冠心病严重程度的生化指标之一。
Objective To investigate whether the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) correlates with the severity of coronary artery disease in patients undergoing percutaneous coronary intervention (PCI) with coronary heart disease. To investigate whether NT-proBNP is an objective biochemical indicator of the severity of coronary heart disease Clinical significance. Methods: A total of 844 patients undergoing coronary angiography with coronary artery angiography and coronary angiography were enrolled in this study. The patients were divided into groups according to coronary artery stenosis Gensini score, different coronary artery lesions and different infarct-related vessels. Variance analysis and 2χ test were used to analyze the differences between groups NT-proBNP levels and cardiac function-related indicators of differences. Results With the increase of lesion count, NT-proBNP level increased, diameter of left atrium increased and left ventricular ejection fraction (LVEF) decreased. With the increase of Gensini score, NT-proBNP level, age of patients and left ventricular diastolic (LVEDd) increased, LVEF decreased, the difference was statistically significant (P <0.05). There was a positive correlation between NT-proBNP and age, left atrium diameter, LVEDd, Gensini score and lesion count, but negatively correlated with LVEF (P <0.01). Conclusion The level of NT-proBNP in patients with coronary heart disease has a certain correlation with the severity of the disease. NT-proBNP may be one of the biochemical markers of the severity of coronary heart disease.