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将手术切除的原发性人胃癌新鲜组织移植于BALB/c裸鼠皮下获得成功,并已传至15代。建立的人胃粘液腺癌裸鼠移植瘤株(GC-916)具有移植成功率高,带瘤时间长的特点。总移植成活率99%,生长潜伏期14天,荷瘤裸鼠最长存活时间为160天,平均带瘤存活时间为89天。经组织学、组织化学、免疫病理学和超微结构观察,证实裸鼠移植瘤保持了原发人体胃癌的结构和功能,并具有表达突变型P_(53)蛋白及产生癌胚抗原的特性。该移植瘤株的建立为进一步研究人胃癌的基础理论和临床治疗提供了较理想的实验动物模型。
Surgically resected fresh human gastric cancer tissue was successfully transplanted subcutaneously into BALB/c nude mice and passed on to 15 generations. The established human gastric mucinous adenocarcinoma nude mouse transplanted tumor strain (GC-916) has the characteristics of high success rate of transplantation and long tumor-bearing time. The total transplant survival rate was 99%, the incubation period was 14 days, the maximum survival time of tumor-bearing nude mice was 160 days, and the average tumor-bearing survival time was 89 days. The histological, histochemical, immunopathological, and ultrastructural observations demonstrated that xenograft tumors in nude mice maintained the structure and function of primary human gastric cancer, and had the characteristics of expressing mutant P53 protein and producing carcinoembryonic antigen. The establishment of the transplanted tumor strain provides an ideal experimental animal model for further research on the basic theory and clinical treatment of human gastric cancer.