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目的探讨鼻咽癌多层螺旋CT灌注成像的临床应用技术。资料与方法22例鼻咽镜活检病理证实的鼻咽癌行多层螺旋CT灌注扫描,经肘静脉注射对比剂,多层螺旋CT对选定的鼻咽层面进行定层连续扫描30次,将4×30帧图像输入functionCT软件内,根据动脉动态增强-时间曲线和各组织强化值计算各层面内每一像素的灌注指标,并计算各指标与同层面正常肌肉的比值,以此来评价鼻咽癌和邻近组织的灌注状态。结果鼻咽癌组织血流量(BF)、强化峰值(PEI)、峰值到达时间(TTP)及血容量(BV)分别为(51.7±10.9)ml.100g-1.min-1、(35.4±5.2)HU、(14.5±1.7)s、(853.6±245.3)ml/100g,肿瘤组织和邻近正常肌肉灌注比值分别为7.0±1.8、4.1±1.4、0.6±0.1、6.9±3.9。结论正确的检查技术是灌注成像的重要保证,多层螺旋CT灌注成像可以显示鼻咽癌微循环灌注特征。
Objective To investigate the clinical application of multi-slice spiral CT perfusion imaging in nasopharyngeal carcinoma. Materials and Methods 22 cases of nasopharyngeal carcinoma confirmed by nasopharyngeal biopsy were performed multi-slice spiral CT perfusion scan. The selected nasopharyngeal layer was continuously scanned 30 times by injection of contrast medium and multi-slice spiral CT in the elbow vein. 4 × 30 frames image input functionCT software, according to arterial dynamic enhancement - time curve and the value of the organization to calculate the level of each pixel perfusion index, and calculate the indicators with the same level of normal muscle ratio, in order to evaluate the nose Pharyngeal cancer and adjacent tissue perfusion state. Results The BF, PEI, TTP and BV of nasopharyngeal carcinoma were (51.7 ± 10.9) ml.100g-1.min-1 and (35.4 ± 5.2) ) HU, (14.5 ± 1.7) s and (853.6 ± 245.3) ml / 100g respectively. The ratios of normal muscle tissue to adjacent tissues were 7.0 ± 1.8, 4.1 ± 1.4, 0.6 ± 0.1 and 6.9 ± 3.9, respectively. Conclusion The correct technique is an important guarantee for perfusion imaging. Multi-slice CT perfusion imaging can show the microcirculation perfusion characteristics of nasopharyngeal carcinoma.