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本文报告1例经手术、病理证实的肺原发性恶性涎腺混合瘤,经检索30年(1965～1995)来国外文献仅得10例。本文结合文献上报导的10例与我院的1例病人,对其组织发生、病理、免疫组化、临床分型及特征、诊断、治疗及预后进行讨论。认为本病病理特点为肿瘤上皮细胞分散于粘液、软骨或玻璃样基质中与S—100蛋白,胶质纤维酸性蛋白(GFAP),肌动蛋白,角蛋白及波纹蛋白胞浆免疫组化反应均阳性。给予临床分型。本病易误诊。首选治疗为手术。预后差。
This paper reports a case of malignant primary parotid mixed tumors confirmed by surgery and pathology. After retrieval for 30 years (1965-1995), only 10 cases were reported in foreign countries. In this paper, 10 cases reported in the literature and one patient in our hospital were studied for histogenesis, pathology, immunohistochemistry, clinical classification and characteristics, diagnosis, treatment and prognosis. The pathological features of this disease were considered as tumor immunohistochemical reactions in which epithelial cells were dispersed in mucus, cartilage or glass-like matrix, and cytoplasm of S-100 protein, glial fibrillary acidic protein (GFAP), actin, keratin, and corrugated protein. Positive. Give clinical classification. The disease is often misdiagnosed. The preferred treatment is surgery. Poor prognosis.