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目的： 探讨贲门癌术前短期化疗与远期生存的关系。方法： 贲门腺癌患者６０ 例， 随机分成用药组与对照组，每组３０ 人。用药组术前分次服用氟脲嘧啶多相脂质体，总剂量为５００ｍｌ。对两组手术切除标本进行大体和病理组织学检查，以及流式细胞荧光ＤＮＡ 凋亡细胞率的检测。结果：与对照组比较，用药组肿瘤体积缩小。癌细胞发生显著的退行性变和坏死。ＤＮＡ 凋亡细胞率明显高于对照组 （ Ｐ＜ ０ ．００１） 。５ 年生存率， 用药组为４０ ．０ ％ ， 对照组为２３ ．３ ％ 。结论：上述结果表明贲门癌患者术前短期服用氟脲嘧啶多相脂质体能提高术后５ 年生存率。
Objective: To investigate the relationship between short-term chemotherapy and long-term survival in patients with cardiac cancer. Methods: Sixty patients with cardia adenocarcinoma were randomly divided into medication group and control group, 30 in each group. The drug group was given fluorouracil multiphase liposomes before surgery, and the total dose was 500 ml. Macroscopic and histopathological examinations were performed on the surgical specimens from both groups, as well as the detection of the rate of apoptotic cells with flow cytometric fluorescent DNA. Results: Compared with the control group, the tumor size of the drug group was reduced. Cancer cells undergo significant degeneration and necrosis. The rate of DNA apoptotic cells was significantly higher than that of the control group (P < 0.001). The 5-year survival rate was 40 for the medication group. 0 %, the control group was 23. 3%. Conclusion: These results suggest that short-term use of fluorouracil multiphasic liposomes before surgery can improve 5-year survival after surgery in patients with cardiac cancer.