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目的:探讨IL-10基因启动子区-627A/C和IL-17基因启动子-152A/G位点多态性与儿童哮喘发生的相关性。方法:采用聚合酶链反应-限制性片段长度多态性分析(PCR-PFLP)方法检测186名哮喘儿童、198名健康儿童各个多态性位点的基因型,采用SPSS13.0进行统计学分析。结果:IL-17基因-152A/G位点的基因型及等位基因频率分布在哮喘组与正常对照组均存在显著性差异(p<0.05),哮喘组-152A/G位点等位基因A频率显著高于正常对照组(x2=6.077,p=0.014,OR=1.430,95%CI=1.076-1.902)。结论:IL-17基因-152A/G位点可能与儿童哮喘的发病存在关系,其中A等位基因可能是易感基因,携带A的个体可能更易患有哮喘。
Aims: To investigate the association of -627A / C and IL-17 gene promoter-152A / G polymorphism in IL-10 gene promoter with childhood asthma. Methods: The genotypes of 186 polymorphic loci in 186 asthmatic children and 198 healthy children were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP). SPSS 13.0 was used for statistical analysis . Results: The genotype and allele frequencies of -152A / G locus in IL-17 gene were significantly different between the asthma group and the normal control group (p <0.05). The allele of -152A / G locus in the asthma group A frequency was significantly higher than the normal control group (x2 = 6.077, p = 0.014, OR = 1.430, 95% CI = 1.076-1.902). CONCLUSION: The -152A / G locus of IL-17 gene may be related to the pathogenesis of childhood asthma. The A allele may be a susceptible gene and the individuals carrying A may be more susceptible to asthma.