目前,大多数癌患者仍然是死于肿瘤的转移。对于肿瘤转移的分子机制,如今已了解得越来越多,因而有望作出新的治疗策略。原发性肿瘤形成子瘤是一个复杂的、由一个个互不相关的步骤组成的系列过程,其中的每个步骤对于转移的形成,都是有限制作用的,即若切断其中的任一步骤,肿瘤的转移就将被阻止。这是对迄今已知的肿瘤转移的各个步骤一个概括,并从而指出了今后肿瘤治疗的新途径。 转移过程的第一步是,癌细胞通过肿瘤组织中细胞与细胞间粘附的松解而脱离出来,然后通过溶蛋白过程而侵入周围的细胞外基质,再进入血管及 At present, most cancer patients still die from the metastasis of the tumor. The molecular mechanism of tumor metastasis is now understood more and more, so it is hopeful to make new treatment strategies. Primary neoplastic neoplasia is a complex series of processes that consist of unrelated steps, each of which has a limiting effect on the formation of metastases, ie, if any of the steps are cut off. The metastasis of the tumor will be stopped. This is a generalization of the various steps of tumor metastasis known so far, and thus points out a new approach to cancer treatment in the future. The first step in the process of metastasis is that cancer cells detach through the release of cell-to-cell adhesion in tumor tissue, then penetrate the surrounding extracellular matrix through the process of protein dissolving, and then enter the blood vessels and