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The intracellular calcium ions(Ca~(2+)) act as second messenger to regulate gene transcription,cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca~(2+)homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis,progression and metastasis. Targeting derailed Ca~(2+)signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca~(2+)channels, transporters and Ca~(2+)-ATPases,which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca~(2+)channels/transporters or Ca~(2+)-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for researchinto the understanding of cellular mechanisms underlying the regulation of Ca~(2+)signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca~(2+)channels or transporters.
The intracellular calcium ions (Ca ~ (2+)) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca ~ (2+) homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca ~ (2+) signaling for cancer therapy has become an emerging research area. This review summarized some important Ca ~ (2+) channels, transporters and Ca ~ (2+ ) -ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca ~ (2+) channels / transporters or Ca ~ (2 +) - ATPase pumps as anti-cancer drugs. This review is also aimed at stimulating interest in, and support for researchinto the understanding of cellular mechanisms underlying the regulation of Ca ~ (2+) signaling in different cancer cells, and to search for novel therapies to cure th ese malignancies by targeting Ca ~ (2+) channels or transporters.