目前,帕金森病的病因不十分清楚,为了更好地理解其病理过程,提出了各种神经变性的机制,包括自由基生成、氧化应激、线粒体异常、兴奋性中毒、钙中毒、营养因子不足、炎症过程、一氧化氮(NO)毒性和细胞调亡。这些因素相互增强形成恶性循环,导致神经功能异常、萎缩,最终导致多巴 Currently, the etiology of Parkinson’s disease is not very clear, in order to better understand the pathological process, put forward a variety of neurodegeneration mechanisms, including free radical generation, oxidative stress, mitochondrial abnormalities, excitotoxicity, calcium poisoning, trophic factor Insufficient, inflammatory processes, nitric oxide (NO) toxicity and apoptosis. These factors reinforce each other to form a vicious cycle, resulting in abnormal nerve function, atrophy, eventually leading to dopa