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本文报道用定量测定血浆血小板 IgG 抗体及定量测定血小板表面相关 IgG 抗体的方法,观察5例儿童、5例成人确诊为自身免疫性血小板减少性紫癜(ITP)患者用大剂量γ球蛋白静脉注射前后的变化,以探讨此治疗方法是否可抑制血小板抗体的产生。结果 10例 ITP 患者用大剂量γ球蛋白治疗后均有疗效,血小板上升。在资料较完整的9例中,有7例的血小板相关 IgG 数量下降。注射γ球蛋白后,所有病例血浆的 IgG 浓度均比治疗前上升。平均升高3.4倍(6.8～23.3ng/ml)。在体外使每例
This article reports the quantitative determination of plasma platelet IgG antibody and platelet surface-related IgG antibody was observed in 5 children, 5 adults diagnosed with autoimmune thrombocytopenic purpura (ITP) patients with high-dose gamma globulin before and after intravenous injection Changes in order to explore whether this treatment can inhibit the production of platelet antibodies. Results 10 cases of ITP patients treated with high-dose γ-globulin are effective, thrombocytopaenia. In the more complete data of 9 cases, 7 cases of platelet-related IgG decreased. After injection of gamma globulin, the plasma IgG levels in all cases were higher than before treatment. An average increase of 3.4 times (6.8 ~ 23.3ng / ml). Make each case in vitro