代谢相关脂肪性肝病的药物治疗进展

来源 :世界临床药物 | 被引量 : 0次 | 上传用户：huanyingchangmaoshou

【摘要】

：

代谢相关脂肪性肝病(MAFLD)是一组高度异质性的多系统疾病,与代谢功能障碍密切相关.随着对MAFLD发病分子机制研究的逐步深入,MAFLD的药物靶点数量大量增加.这些药物作用于不同的病理生理过程,如脂质代谢、胰岛素抵抗、葡萄糖稳态、氧化应激、炎症或纤维化.本文针对不同作用靶点,将MAFLD的治疗药物研究进展进行概述,以期为MAFLD治疗提供参考.

【作者】

：

石洁苏青范建高杨震

【机构】

：

上海交通大学医学院附属新华医院内分泌科,上海200092;上海交通大学医学院附属新华医院消化内科,上海200092

【出处】

：

世界临床药物

【发表日期】

：

2021年8期

【关键词】

：

代谢相关脂肪性肝病药物治疗进展

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Quantized tracking control for nonlinear systems with unstable linearization

Dear editor,rnOutput tracking control is currently receiving increased at-tention because of its applications in various fields[1-3].Controller design for nonlinear systems with unstable lin-earization[4]is essential because such systems have several appl

期刊

Suboptimal adaptive tracking control for FIR systems with binary-valued observations

In this paper,we investigate and analyze the suboptimal adaptive control for finite impulse re-sponse(FIR)systems with binary-valued observations.As the parameters of FIR systems are unknown and the measurable observations can only provide limited informa

期刊

parameter identificationFIR systemsbinary-valued observationsasymptotically s

Experimental progress in nonadiabatic geometric gates with a superconducting qubit

Quantum computation can be performed via a universal set of quantum gates,such as two non-commuting one-qubit gates and a nontrivial two-qubit gate,which are actually unitary evolutions governed by the Hamiltonian of a quan-tum system.Different from dynam

期刊

Distributed event triggering control for six-rotor UAV systems with asymmetric time-varying output c

Inspired by the practical operability and safety of unmanned aerial vehicles(UAVs)in confined areas,this paper investigates adaptive trajectory tracking control problems in multiple six-rotor UAV sys-tems with asymmetric time-varying output constraints an

期刊

adaptive neural controlasymmetric time-varying output constraintsevent trigger

Containment control of multi-agent systems with nonvanishing disturbance via topology reconfiguratio

Dear editor,rnMulti-agent systems(MASs)are ubiquitous in natural as well as artificial systems.Over the past several decades,an increasing number of researchers have devoted attention to distributed cooperative control problems of MASs such as mobile robo

期刊

Vibrational characteristics of rotating soft cylinders

Rotating structural components are omnipresent in engineering structures and natural world.This work investigates the effects of the centrifugal and Coriolis forces on the free vibrational characteristics of soft cylinders rotating with respect to the axi

期刊

rotating soft cylindersvibrational characteristicscentrifugal forceCoriolis f

Model predictive control with fractional-order delay compensation for fast sampling systems

Model predictive control(MPC)is widely used in fast sampling systems owing to its fast reg-ulating ability.However,the sampling delay is a key issue and tends to be a fractional multiple of the sampling period.If the fractional-order delay is not accurate

期刊

model predictive controlfast sampling systemssampling delayfractional-orderL

Quantum model for understanding protein misfolding behavior—phase diagram and manual intervention

The study of protein folding is fundamental and important in the multidisciplinary field because a diversity of diseases,like Alzheimer\'s and Parkinson\'s are relevant to protein misfolding.The current thermodynamic and geometric approaches only phen

期刊

quantum phase diagramquantum walkmean first-passage timeprotein folding

Topology change and emergent scale symmetry in compact star matter via gravitational wave detection

Topological structure has been extensively studied and confirmed in highly correlated condensed matter physics.We explore the gravitational waves emitted from binary neutron star mergers using the pseudoconformal model for dense nuclear matter for compact

期刊

topology changeemergent symmetrycompact star mattergravitational wave

Test of a model coupling of electromagnetic and gravitational fields by using high-frequency gravita

Models of the coupling of electromagnetic and gravitational fields have been studied extensively for many years.In this paper,we consider the coupling between the Maxwell field and the Weyl tensor of the gravitational field to study how the wavevector of

期刊

modified theorygravitational wavewave vector

代谢相关脂肪性肝病的药物治疗进展

与本文相关的学术论文