The safety and stability study on Northeast, North, East, Northwest and Central China power grids had been carried out, which provided technical supports to planning design of regional power grids. By analyzing safety and stability under severe faults in regional power grids, revealed weaknesses on power grid configurations and measures for preventing from loss of stability were presented. In comparison of various schemes of power system safety and stability among parts of power grids, more than two recommended schemes can be chosen as reference in planning design for regional power grids. Considering the safety and stability control measures necessary for each power grids, it is believed the trunk networks of all power grids can fulfill the third criteria of Guideline for Power System Safety and Stability, while the weakness and predominated hydropower may deteriorate safety and stability of power grids. The power grid shall be regulated in line with the variation of boundary conditions.