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目的 :为精神药物的中毒鉴定提供方法和依据。方法 :调查精神病患者头发中药物的存在状况 ,并建立头发中抗抑郁药和抗精神病药的GC/NPD和GC/MS分析方法。结果 :在32名精神病患者头发中检出了卡马西平、阿米替林、多虑平、安坦、氯丙嗪、泰尔登、三氟拉嗪、氯氮平等八种抗忧郁药和抗精神病药 ;并发现头发中氯丙嗪和氯氮平含量与剂量存在相关关系 ,相关系数分别为0 8047(P<0 001,n=16)和0 7097(P<0 001,n=16);且头发分段分析表明药物在毛干中的分布与用药史一致。结论 :头发分析可提供精神药物剂量史的信息 ,检出时限至少为药后16个月。
Objective: To provide methods and basis for the identification of psychotropic substances. METHODS: The presence of medications in the hair of mentally ill patients was investigated and GC / NPD and GC / MS analyzes of antidepressants and antipsychotics in the hair were established. Results: Eight antidepressants such as carbamazepine, amitriptyline, doxepin, antan, chlorpromazine, telfon, trifluoperazine and clozapine were detected in the hair of 32 psychiatric patients. Antipsychotics; and found that the hair chlorpromazine and clozapine content and dose relationship, the correlation coefficients were 0 8047 (P <0 001, n = 16) and 0 7097 (P <0 001, n = 16 ); And hair segmentation analysis showed that the distribution of drugs in the hair shaft consistent with the medication history. Conclusion: Hair analysis provides information on the history of psychotropic drug doses, with a detection limit of at least 16 months after dosing.