目的:研究2-甲氧羰基-4-芳基噻吩衍生物的合成工艺。方法:以相应的芳基乙酸为原料在V ilsm e ir-Haack条件下制备V inam id in ium盐,在甲醇钠-甲醇碱性溶剂体系与巯基乙酸甲酯回流,制备2-甲氧羰基-4-芳基噻吩衍生物。结果:合成了10个目标化合物,其中5个为新化合物。化合物结构经核磁共振氢谱和高分辨质谱确证。结论:发现一个新的2-甲氧羰基-4-芳基噻吩衍生物的合成方法,反应条件温和,操作简单,收率高,并提出了可能的反应机制。 Objective: To study the synthesis of 2-methoxycarbonyl-4-arylthiophene derivatives. Methods: Viminidium salt was prepared from the corresponding aryl acetic acid under Vilms eir-Haack conditions and refluxed in sodium methoxide-methanol basic solvent with methyl mercaptoacetate to prepare 2-methoxycarbonyl- 4-Arylthiophene derivatives. Results: Ten target compounds were synthesized, of which five were new compounds. The structures of the compounds were confirmed by 1H NMR and HRMS. CONCLUSION: A new synthesis method of 2-methoxycarbonyl-4-arylthiophene derivatives has been found. The reaction conditions are mild, the operation is simple, the yield is high, and the possible reaction mechanism is proposed.