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目的探讨系统性红斑狼疮(SLE)患儿治疗前后抗核抗体(ANA)滴度及荧光模型表达的变化。方法 45例SLE患儿给予肾上腺皮质激素泼尼松治疗,直至转为非活动期。用间接免疫荧光法检测激素治疗前后血清ANA滴度及荧光模型。结果 45例患儿治疗前后ANA阳性率分别为97.8%(44/45)、95.6%(43/45),治疗前后比较差异无统计学意义(P>0.05);治疗前后ANA阳性SLE患儿ANA滴度分布比较,差异有统计学意义(P<0.05),治疗后ANA高滴度(≥1∶3 200)比例降低。治疗前后ANA阳性SLE患儿ANA荧光模型构成比比较,差异无统计学意义(P>0.05)。结论检测ANA对诊断与治疗儿童SLE有重要意义,治疗前后ANA荧光模型表达的变化是否能反映病情与治疗效果有待进一步研究。
Objective To investigate the changes of antinuclear antibody (ANA) titer and fluorescence model before and after treatment in children with systemic lupus erythematosus (SLE). Methods Forty-five children with SLE received adrenocorticotropic prednisone until they became inactive. Indirect immunofluorescence was used to detect serum ANA titer and fluorescence model before and after hormone therapy. Results The positive rates of ANA in 45 children before and after treatment were 97.8% (44/45) and 95.6% (43/45), respectively. There was no significant difference between before and after treatment (P> 0.05) The titer distribution was significantly different (P <0.05). After treatment, the high titer of ANA (≥1: 300) decreased. Before and after treatment ANA positive SLE children ANA fluorescence model comparison, the difference was not statistically significant (P> 0.05). Conclusion The detection of ANA is of great significance in the diagnosis and treatment of children with SLE. Whether the changes of ANA fluorescence model before and after treatment can reflect the condition and treatment needs further study.