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本文报告恶性卵黄囊瘤19例,按组织形态分为两型,即典型和分化差型。年龄以11-15岁最常见,占84.1％。一年死亡率为94.7％。术后AFP测定的应用,可作为观察疗效、有无复发或转移的指标。组织发生与早期胚胎卵黄囊是同系而来的一种原始生殖细胞衍化而来的肿瘤,同时与生殖细胞源性其他肿瘤密切相关,可以互相混杂或并存。本瘤因分化的差异,组织形态多种变化,因此不要求具备所有形志特征后再确诊,一般只要求有1-2种典型结构(星网状结构或内胚窦样结构)即可确诊本瘤。按命名原则,我们认为称为恶性卵黄囊瘤较合理。
This article reports 19 cases of malignant yolk sac tumor, divided into two types according to the histological morphology, that is, typical and poor differentiation. The oldest is 11 to 15 years old, accounting for 84.1%. One-year mortality rate was 94.7%. Postoperative AFP determination of the application, can be used as an indicator of efficacy, recurrence or metastasis. Tissue occurs with the early embryo yolk sac is homologous to a primordial germ cell derived from the tumor, while closely related to other germ cell tumors, can be mixed with each other or co-exist. The tumor due to differentiation differences, a variety of changes in tissue morphology, and therefore do not require all the signs and characteristics of the diagnosis, usually only requires 1-2 kinds of typical structures (star network structure or endoderm sinusoid structure) can be diagnosed The tumor. According to the nomenclature, we consider it more reasonable to refer to malignant yolk sac tumors.