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目的:对米索前列醇应用于产后出血的临床预防效果和安全性进行分析。方法:采用回顾式分析,选择从2010年8月至2013年8月期间入我院生产的,有着高危出血因素的产妇100例进行临床观察分析,按照入院先后顺序,将100例产妇随机分成两组,一组为对照组50例产妇,观察组50例产妇。观察组在胎儿分娩中,胎前肩分娩出时,对产妇使用口服的米索前列醇400μg;对照组50例产妇,在胎前肩分娩出来后,对产妇进行静脉10%葡萄糖溶液的注射,同时,要使用20U缩宫素。而产妇的出血量可以使用容积法或者卫生纸称重法进行计算。结果:观察组的50例产妇在产后2h的出血量达到了(206.1±34.5)ml,而对照组的50例产妇在产后2h的出血量达到了(295.6±38.6)ml,观察组的预防效果要明显优于对照组,差异对比明显,具有统计学意义(P<0.05)。观察组中50例产妇仅有一例出现产后出血,而对照组50例产妇有5例出现产后出血,观察组与对照组进行对比,具有显著差异,观察组明显要优于对照组的治疗效果,具有统计学意义(P<0.01)。结论:产妇使用米索前列醇可以有效进行产后出血的预防,米索前列醇使用十分方便,具有极高的安全性,可以有效预防产妇的产后出血,建议推广临床使用。
Objective: To analyze the clinical efficacy and safety of misoprostol in postpartum hemorrhage. Methods: A retrospective analysis was used to select 100 maternal high-risk bleeding patients who were admitted into our hospital from August 2010 to August 2013. 100 maternal women were randomly divided into two groups according to admission sequence Group, a group of 50 maternal women in the control group, observation group 50 maternal. Observation group in the fetus childbirth, childbirth anterior fetal delivery, the use of oral misoprostol for mothers 400μg; control group of 50 mothers, the anterior fetal shoulder after delivery, the mother of 10% intravenous injection of glucose solution, At the same time, to use 20U oxytocin. The amount of maternal bleeding can be calculated using the volume method or toilet paper weighing method. Results: The bleeding volume of 50 maternal women in observation group reached (206.1 ± 34.5) ml at 2h postpartum and that of 50 maternal women in control group reached 295.6 ± 38.6 mL at 2h postpartum. The preventive effect of the observation group To be significantly better than the control group, the difference was significant, with statistical significance (P <0.05). In the observation group, only 50 cases of maternal postpartum hemorrhage occurred in 50 cases, while 50 cases in the control group had postpartum hemorrhage in 5 cases. There was significant difference between the observation group and the control group, and the observation group was obviously better than the control group. With statistical significance (P <0.01). Conclusion: Maternal application of misoprostol can effectively prevent postpartum hemorrhage. Misoprostol is very convenient to use. It has high safety and can effectively prevent postpartum hemorrhage. It is recommended to promote clinical use.