细胞外基质(extracellular matrix,ECM)的合成或降解代谢失衡与许多肾脏疾病的发生有关,基质金属蛋白酶(matrixmetalloproteinases,MMPs)是降解细胞外基质的重要酶类。近年来研究表明,肾缺血再灌注后早期MMPs的表达及酶活性增强,并通过降解细胞外基质参与肾缺血再灌注损伤的发 The synthesis or degradation of extracellular matrix (ECM) imbalances are associated with the development of many kidney diseases. Matrix metalloproteinases (MMPs) are important enzymes that degrade extracellular matrix. In recent years, studies have shown that, early renal ischemia-reperfusion MMPs expression and enzyme activity increased, and by degrading the extracellular matrix involved in renal ischemia-reperfusion injury