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目的:探讨新生儿母子ABO血型不合溶血病应用不同比例成分血换血治疗情况。方法:选取达换血指征的ABO血型不合溶血病患儿60例,均为我院2015年1月至2016年2月收治,应用不同比例成分血换血术治疗,血源均为O型浓缩红细胞及AB型血浆。随机分组,就2.5:1比例(观察组,n=30)与2:1比例(对照组,n=30)患儿血清总胆红素、血红蛋白等指标变化情况展开对比。结果:两组换血后血清总胆红素均显著下降,与换血前比较均有统计学差异(P<0.05),但观察组下降幅度较对照组更为显著(P<0.05)。对照组换血前后红细胞压积、血红蛋白差异明显(P<0.05)。观察组红细胞压积及血红蛋白下降均不明显(P>0.05)。血清中重要电解质K+、Cl-换血前后变化均不明显(P>0.05)。结论:采用2.5:1配比的O型浓缩红细胞及AB型血浆成分血换血对HDN治疗,可促血清胆红素水平迅速降低,又可对贫血有预防作用,且换血前后血清电解质差异不明显,有较高应用价值。
Objective: To explore neonatal mother and child ABO incompatible hemolytic disease with different proportions of blood transfusions treatment. Methods: A total of 60 children with ABO incompatible hemolytic disease were selected for transfusion. All of them were admitted to our hospital from January 2015 to February 2016 and were treated with blood transfusions in different proportions. The blood was all O-type red blood cells And AB type plasma. Randomly divided groups were compared on the changes of serum total bilirubin and hemoglobin in the ratio of 2.5: 1 (observation group, n = 30) and 2: 1 ratio (control group, n = 30). Results: Serum total bilirubin was significantly decreased after transfusion in both groups (P <0.05), but the decrease in observation group was more significant than that in control group (P <0.05). The hematocrit and hemoglobin in the control group before and after transfusion were significantly different (P <0.05). The observation group, hematocrit and hemoglobin decreased significantly (P> 0.05). Serum K +, Cl-exchange of important electrolytes before and after changes were not significant (P> 0.05). CONCLUSION: The treatment of HDN with blood transfusions of type O concentrated red blood cells and type AB plasma components with a ratio of 2.5: 1 can rapidly reduce serum bilirubin levels and prevent anemia, and the serum electrolytes did not change significantly before and after blood exchange , Have higher application value.