论文部分内容阅读
目的分析颅咽管瘤术前泌乳素(PRL)、促甲状腺激素(TSH)和促肾上腺皮质激素(ACTH)的变化,探讨术前激素变化与术后尿崩症的关系,为术后并发症的防治及预后的评估提供参考依据。方法对2003年3月-2007年6月收治的96例颅咽管瘤患者进行回顾性分析。对患者术前的激素(PRL、TSH及ACTH)检测结果与术后尿崩症的关系进行分析;按照术前有异常的激素种类将患者分为Ⅰ组(术前无激素的改变)、Ⅱ组(术前有任意1种激素发生改变)、Ⅲ组(术前有任意2种激素发生改变)及Ⅳ组(术前3种激素都发生改变)组。分析不同组别与术后尿崩症的关系。结果术前PRL、TSH及ACTH有改变的患者术后尿崩症发生率高于术前上述激素无改变的患者,PRL、TSH及ACTH发生改变的种类越多,术后尿崩症发生率越高。结论术前PRL、TSH及ACTH的改变和改变的种类多少可以作为判定术后并发症和评估预后的参考指标之一。
Objective To analyze the changes of preoperative prolactin (PRL), thyrotropin (TSH) and adrenocorticotrophic hormone (ACTH) in craniopharyngioma and to explore the relationship between preoperative hormone changes and postoperative diabetes insipidus, Prevention and prognosis of the assessment provide a reference. Methods The clinical data of 96 patients with craniopharyngioma admitted from March 2003 to June 2007 were analyzed retrospectively. Preoperative hormones (PRL, TSH and ACTH) test results and postoperative diabetes insipidus analysis; according to the type of preoperative abnormal hormones patients were divided into Ⅰ group (preoperative hormone-free changes), Ⅱ Group (any one kind of hormone was changed preoperatively), group Ⅲ (any two kinds of hormone changed preoperatively) and group Ⅳ (all three kinds of hormone changed before operation). Analysis of different groups and postoperative diabetes insipidus relationship. Results The preoperative incidence of postoperative diabetes insipidus was significantly higher in patients with preoperative PRL, TSH and ACTH changes than those without preoperative hormonal changes. The more categories of PRL, TSH and ACTH were changed, the more incidence of postoperative diabetes insipidus high. Conclusions The preoperative changes of PRL, TSH and ACTH and the types of changes can be used as a reference to determine postoperative complications and prognosis.