论文部分内容阅读
目的对环氧合酶2与肿瘤的关系做出更为准确的结论。方法通过检索相关文献,共收集了25个病例对照研究结果,包含9482例肿瘤患者,12206位正常个体。通过对以往的研究结果进行meta分析,使用OR值和95%可信区间(CI)衡量基因与肿瘤的关联强度。结果突变的基因型可以增加肿瘤的发病风险(AA/AG vs GG,OR=1.15,95%CI:1.02~1.31)。按照种群分层显示:突变的基因型增加亚洲人群的发病(AA/AG vs GG,OR=1.28,95%CI:1.12~1.46)。根据肿瘤类型分层,除了在食道癌和“其他”分组中之外,并未发现基因突变与肿瘤之间存在相关性。结论环氧合酶2-1195G>A突变可能是肿瘤发生的潜在风险因素。
Objective To make a more accurate conclusion about the relationship between cyclooxygenase 2 and tumor. METHODS: A total of 25 case-control studies were collected by searching relevant literature, including 9482 cancer patients and 12206 normal individuals. Through the meta-analysis of previous studies, OR and 95% confidence interval (CI) were used to measure the association between tumor and gene. Results Mutant genotypes increased the risk of developing tumors (AA / AG vs GG, OR = 1.15, 95% CI: 1.02-1.31). Stratification by population showed that the mutant genotype increased the incidence of the Asian population (AA / AG vs GG, OR = 1.28, 95% CI: 1.12-1.46). Stratification by tumor type did not reveal a correlation between the mutation and the tumor except in esophageal cancer and the “other” subgroup. Conclusions Mutation of cyclooxygenase 2-1195G> A may be a potential risk factor for tumorigenesis.