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目的对ICU有机磷农药中毒发生呼吸衰竭患者在机械通气期间用右美托咪定镇静效果的观察。方法随机选取有机磷农药中毒发生呼吸衰竭使用呼吸机患者28例，在机械通气期间使用右美托咪定镇静，观察用药前、用药后患者的心率、呼吸、血压、气道压力、氧合指数等参数的变化并进行比较。结果右美托咪定对有机磷农药中毒发生呼吸衰竭机械通气患者能够快速镇静，降低气道压力，稳定心率和循环，用药后患者心率、血压、呼吸次数、氧合指数有明显改善(<0.05)。结论右美托咪定是ICU有机磷农药中毒呼吸衰竭患者使用机械通气时的理想镇静剂。“,”Objective To study the ef ect of sedative of dexmedetomidine in mechanical ventilation patients with organophosphorus pesticide poisoning in ICU. Methods 28 patients of organophosphorus pesticide poisoning with respiratory failure in mechanical ventilation were treated wih dexmedetomidine.The HR,RR, SBP,DBP,Airway Pressure ,Oxygenation index of patients were measured before treatment and after treatment, then the results were compared.Results Rapid sedation with dexmedetomidine weredisplayed in patients of organophosphorus pesticide poisoning with respiratory failure in mechanical ventilation,and airway pressure was reduced, heart rate and circulation were stabled, The HR,BP,RR, and Oxygenation index were changed significantly ( <0. 05).Conclusion Dexmedetomidine is an ideal sedative drug in patients with organophosphorus pesticide poisoning with respiratory failure in mechanical ventilation in ICU.