论文部分内容阅读
目的:研究奥硝唑治疗滴虫性阴道炎的疗效及其对治疗前后患者阴道分泌物中细胞因子IL-2、IL-8和IL-13的影响。方法:将滴虫性阴道炎患者按就诊顺序分为观察组和对照组各70例,观察组使用奥硝唑治疗,对照组使用甲硝唑治疗,评价治疗的效果并检测治疗前后阴道灌洗液中IL-2、IL-8和IL-13的变化。结果:服药7天后,观察组的治疗效果优于对照组,总有效率分别为94.28%和85.71%,差异有统计学意义(P<0.05)。两组患者治疗后阴道灌洗液中的IL-2、IL-8和IL-13均下降,观察组的下降值明显高于对照组。结论:奥硝唑治疗滴虫性阴道炎疗效显著,并能有效降低阴道分泌物中IL-2、IL-8和IL-13的水平,改善阴道的微环境,可在临床治疗广泛使用。
Objective: To investigate the efficacy of ornidazole in the treatment of trichomonas vaginitis and its effect on the secretion of cytokines IL-2, IL-8 and IL-13 in patients before and after treatment. Methods: The patients with trichomonas vaginitis were divided into the observation group and the control group according to the order of treatment, 70 cases in each group. The observation group was treated with ornidazole, the control group was treated with metronidazole, the effect of treatment was evaluated, and the vaginal lavage Changes of IL-2, IL-8 and IL-13 in fluid. Results: After 7 days of treatment, the therapeutic effect of the observation group was better than that of the control group. The total effective rates were 94.28% and 85.71% respectively. The difference was statistically significant (P <0.05). After treatment, the levels of IL-2, IL-8 and IL-13 in vaginal lavage fluid decreased in both groups, and the decrease in observation group was significantly higher than that in control group. CONCLUSION: Ornidazole is effective in treating trichomonas vaginitis and can effectively reduce the levels of IL-2, IL-8 and IL-13 in vaginal secretions and improve vaginal microenvironment, which can be widely used in clinical treatment.