肝细胞是载脂蛋白AI和ATP结合盒转运体A1表达的主要部位,也是循环中高密度脂蛋白的主要来源。在培养的原代肝细胞用氚标磷脂酰胆碱和氚标低密度脂蛋白胆固醇标记细胞表面,或者用氚标甲羟戊酸标记新合成胆固醇,就可发现新合成的载脂蛋白AI的细胞内脂化作用的某些特征。在内质网 Hepatocytes are the major site for the expression of apolipoprotein AI and ATP-binding cassette transporter A1 and are also the major source of circulating high density lipoproteins. The newly synthesized apolipoprotein AI can be found by labeling the cell surface with tritiated phosphatidylcholine and tritiated low-density lipoprotein cholesterol in cultured primary hepatocytes or by labeling the newly synthesized cholesterol with tritoran methionine Some features of intracellular lipidation. In the endoplasmic reticulum