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目的探讨妊娠期高血压疾病患者胎盘组织中凋亡相关蛋白Survivin的表达情况及意义。方法选择2010年8月至2011年4月在北京军区总医院住院分娩的妊娠期高血压疾病患者共44例(妊娠期高血压疾病组),其中妊娠期高血压孕妇15例(妊娠期高血压组),轻度子痫前期孕妇14例(轻度子痫前期组),重度子痫前期孕妇15例(重度子痫前期组);以同期正常晚期妊娠孕妇16例为对照组。采用免疫组化法检测各组孕妇胎盘组织中Survivin表达水平。结果妊娠期高血压疾病组与对照组比较胎盘组织中Survivin的表达明显降低,差异有极显著性(U=3.504,P<0.01),妊娠期高血压组、轻、重度子痫前期组间Survivin表达逐渐减弱,差异有显著性(P<0.05)。结论 Survivin在妊娠期高血压疾病患者尤其是在重度子痫前期胎盘中的表达降低可能与妊娠期高血压疾病的发生发展密切相关。
Objective To investigate the expression and significance of apoptosis-related protein Survivin in placenta of patients with gestational hypertension. Methods Forty-four patients with gestational hypertension (gestational hypertension group) were hospitalized in Beijing Military General Hospital from August 2010 to April 2011. Among them, 15 were pregnant women with gestational hypertension (gestational hypertension Group), 14 pregnant women with mild preeclampsia (mild preeclampsia group) and 15 pregnant women with severe preeclampsia (severe preeclampsia group); 16 pregnant women with normal late pregnancy as the control group. The expression of Survivin in placenta was detected by immunohistochemistry. Results Compared with the control group, the expression of Survivin in gestational hypertension group was significantly lower than that in the control group (U = 3.504, P <0.01). The expression of Survivin in gestational hypertension group, mild and severe preeclampsia group was significantly higher than that in control group The expression gradually weakened, the difference was significant (P <0.05). Conclusion The decreased expression of survivin in patients with gestational hypertension, especially in severe preeclampsia may be closely related to the occurrence and development of hypertensive disorder complicating pregnancy.