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采用Ⅳ型胶原抗体用ＬＳＡＢ免疫组化方法对１８例胸腺瘤内Ⅳ型胶原的分布进行研究，所有病例分别根据Ｓａｙｌｅｒ和Ｅｇｇｌｅｓｔｏｎ及Ｍａｒｉｎｏ和Ｍｉｌｅｒ－Ｈｅｒｍｅｌｉｎｋ的分类方法进行分类。结果显示：采用Ｍａｒｉｎｏ和Ｍｉｌｅｒ－Ｈｅｒｍｅｌｉｎｋ分类方法，Ⅳ型胶原分布和胸腺瘤组织学类型及病人临床阶段明显相关；而采用Ｓａｙｌｅｒ和Ｅｇｇｌｅｓｔｏｎ分类方法则相反。因此建议：Ｍａｒｉｎｏ和Ｍｕｌｅｒ－Ｈｅｒｍｅｌｉｎｋ分类方法能反映病人的预后。
The distribution of type IV collagen in 18 cases of thymoma was studied by LSAB immunohistochemistry using type IV collagen antibodies. All cases were classified according to the classification methods of Sayler and Eggleston and Marino and Miler-Hermelink. The results showed that using the Marino and Miler-Hermelink classification methods, the type IV collagen distribution was significantly correlated with the histological type of thymoma and the patient’s clinical stage, while the use of the Sayler and Eggleston classification methods was the opposite. Therefore it is recommended that the Marino and Muler-Hermelink classification methods reflect the patient’s prognosis.