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目的：研究利福平白蛋白微球的制备和体外释放。方法：选用戊二醛为交联剂，采用聚合物分散法制备利福平白蛋白微球。结果：所得微球粒径范围为１０～３０μｍ，微球中利福平含量为２３．５±０．８％（ｗ／ｗ）。扫描电镜下观察载药微球呈圆形，但表面不光滑，有未洗脱的药物微粒存在。体外释放实验结果显示，利福平微球体外释放符合Ｈｉｇｕｃｈｉ方程，具有明显的缓释作用。结论：利福平适于制成微球制剂。
Objective: To study the preparation and in vitro release of rifampicin albumin microspheres. Methods: Glutaraldehyde was used as crosslinking agent to prepare the rifampin albumin microspheres by polymer dispersion method. Results: The size of the obtained microspheres ranged from 10 to 30 μm, and the content of rifampin in the microspheres was 23.5 ± 0.8% (w / w). Scanning electron microscopy showed that the drug-loaded microspheres were round, but the surface was not smooth, there are non-eluting drug particles exist. In vitro release experiments showed that in vitro release of rifampicin microspheres consistent Higuchi equation, with a significant sustained release. Conclusion: Rifampicin is suitable for preparation of microsphere preparation.