Objective To evaluate the effect of simple method and the composite method of carbon tetrachloride (CCl4) in establishment of rabbit model of hepatic fibrosis. Methods Totaly 20 male healthy rabbits were randomly and averagely divided into two groups.The simplex method group was only given a subcutaneous injection of pure CCl4 (at 0.5ml/kg,twice a week).On this basis,the composite method group accompanied by feeding high-fat and low-protein food,and diluted to 10% ethanol as the only beverage.The effect of the two methods were comparative studied. Results Death of the models usualy happened within 4 weeks after first injection and became stable after 5 weeks. Although the total success rate of the liver fibrosis in composite method group was 70%,but 100% of the survival rabbits were fibrosis at 8 weeks,and al of the survived rabbits developed into cirrhosis at 12 weeks. Conclusion Composite method of CCl4 is a better method in establishment of hepatic fibrosis model.