Net是三元复合因子家族中的一员,是一种重要的转录调节因子,尤其对原癌基因c-fos的转录具有重要的调节作用,而c-fos基因与细胞的增殖、分化以及某些肿瘤的发生密切相关。c-fos启动子是Net的调节靶点,Net在c-fos启动子的血清反应元件上与血清反应因子结成三元复合体,从而实现其调节功能;且随着细胞内生物环境不同,其表现的调节功能亦不同。 Net is a member of the ternary complex factor family, an important transcriptional regulator, especially for the transcription of proto-oncogene c-fos has an important regulatory role, and c-fos gene and cell proliferation, differentiation and a The occurrence of these tumors is closely related. c-fos promoter is a regulatory target of Net. Net forms a ternary complex with serum response factors on the c-fos promoter’s serum response elements to regulate its function. With the different biological environment in cells, The performance of its performance is also different.