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目的:探讨小剂量低分子肝素治疗急性早幼粒细胞白血病弥漫性血管内凝血(DIC)的疗效及其安全性。方法:初次接受治疗的40例急性早幼粒细胞白血病(APL)患儿随机分成两组,小剂量低分子肝素治疗组(A组)20例,常规治疗组20例,比较两组的DIC发生率和完全缓解率。结果:低分子肝素治疗组DIC的发生率较常规治疗组低(P<0.05),而完全缓解率差异无统计学意义(P>0.05)。结论:小剂量低分子肝素可以有效减少急性早幼粒细胞白血病患儿DIC的发生,具有良好的安全性。
Objective: To investigate the efficacy and safety of low-dose low molecular weight heparin in the treatment of diffuse intravascular coagulation (DIC) in acute promyelocytic leukemia. Methods: Forty patients with acute promyelocytic leukemia (APL) who were treated for the first time were randomly divided into two groups: 20 in low-molecular-weight heparin group (group A) and 20 in conventional treatment group Rate and complete remission rate. Results: The incidence of DIC in low molecular weight heparin treatment group was lower than that in conventional treatment group (P <0.05), but the complete remission rate had no significant difference (P> 0.05). Conclusion: Low-dose LMWH can effectively reduce the incidence of DIC in children with acute promyelocytic leukemia and has good safety.