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目的:评价长期家庭氧疗结合肺脏康复训练在慢性阻塞性肺疾病(COPD)患者稳定期康复治疗中的疗效。方法:40例需要接受长期家庭氧疗的COPD患者按随机数字表法随机分为治疗组20例和对照组20例。治疗组接受常规治疗及家庭氧疗(LTOT)同时进行肺脏康复训练,氧流量2.5L/min,每天吸氧时间不少于15小时。对照组只接受常规治疗。分析患者治疗前及治疗后的肺通气功能和动脉血气分析;6分钟步行距离及生活质量评分的变化。结果:2年后治疗组死亡3例,病死率15%,对照组死亡5例,病死率25%,2组比较差异无统计学意义(P﹥0.05);2年后治疗组第1秒用力呼气容积(FEV1)1.43±0.08L,用力肺活量(FVC)2.53±0.20L,对照组(FEV1)1.37±0.12L,用力肺活量(FVC)2.19±0.18L。2组比较差异无统计学意义(P﹥0.05);2组2年后6分钟步行距离及生活质量评分对比,差异无统计学意义。结论:稳定期COPD患者长期家庭氧疗结合肺脏康复训练能缓解呼吸困难症状,改善运动能力和提高生活质量,值得推广应用
Objective: To evaluate the long-term home oxygen therapy combined with lung rehabilitation training in patients with chronic obstructive pulmonary disease (COPD) stable rehabilitation. Methods: Forty COPD patients undergoing long-term home oxygen therapy were randomly divided into treatment group (20 cases) and control group (20 cases) according to the random number table method. The treatment group received routine treatment and home oxygen therapy (LTOT) while lung rehabilitation training, oxygen flow 2.5L / min, oxygen daily oxygen time of not less than 15 hours. The control group received routine treatment only. Analysis of pulmonary function and arterial blood gas analysis before and after treatment; 6-minute walking distance and quality of life changes. Results: After 2 years, there were 3 deaths in the treatment group, with a mortality rate of 15% and 5 deaths in the control group with a mortality rate of 25%. There was no significant difference between the two groups (P> 0.05) Expiratory volume (FEV1) of 1.43 ± 0.08L, forced vital capacity (FVC) of 2.53 ± 0.20L, FEV1 of 1.37 ± 0.12L and forced vital capacity (FVC) of 2.19 ± 0.18L. There was no significant difference between the two groups (P> 0.05). There was no significant difference in gait distance and quality of life score between two groups at 6 minutes after 2 years. Conclusion: Long-term home oxygen therapy combined with lung rehabilitation training can alleviate the symptoms of dyspnea, improve the exercise capacity and improve the quality of life in patients with stable COPD, which is worth popularizing and applying