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A novel compound N-phenethyl-4-hydroxy-4-phenyl piperidine hydrochloride (C19H24ClNO·H2O) has been synthesized and structurally characterized by elemental analysis, IR, 1H NMR spectra and single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group P212121 with a = 8.6306(8), b = 11.0464(10), c = 19.3221(18) , V = 1842.1(3)3, Z = 4, Dc =1.211 g/cm3, μ = 0.217 mm-1, Mr = 335.86, F(000) = 720, S = 0.973, R = 0.0420 and wR = 0.1009 for 3627 unique reflections with 3157 observed ones (I > 2σ(I)). In the crystal, the dihedral angles made by piperidine ring with two benzene rings are 84.8(6) and 62.5(7)°, respectively. Intermolecular O–H…O and O–H…Cl hydrogen bonds involving water molecules form chains along the b axis, which stabilizes the crystal structure. The preliminary bioactivity tests indicated that the title compound has good effect of cellular growth inhibition to K562 cells and potential bioactivity of anti-leukemia.
A novel compound N-phenethyl-4-hydroxy-4-phenyl piperidine hydrochloride (C19H24ClNO · H2O) has been synthesized and structurally characterized by elemental analysis, IR, 1H NMR spectra and single-crystal X-ray diffraction. The crystal belongs to orthorhombic , space group P212121 with a = 8.6306 (8), b = 11.0464 (10), c = 19.3221 18, V = 1842.1 (3) 3, Z = 4, Dc = 1.211 g / cm3, M-1, Mr = 335.86, F (000) = 720, S = 0.973, R = 0.0420 and wR = 0.1009 for 3627 unique reflections with 3157 observed ones (I> 2σ (I)). made by piperidine ring with two benzene rings are 84.8 (6) and 62.5 (7) °, respectively. Intermolecular O-H ... O and O-H ... Cl hydrogen bonds involving water molecules form chains along the b axis, which stabilizes the crystal structure. The preliminary bioactivity tests indicated that the title compound has good effect of cellular growth inhibition to K562 cells and potential bioactivity of anti-leukemia.