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目的:观察早期干预对早产儿智力、运动能力及脑瘫发生的影响。方法:对2001年9月—2003年9月在我科新生儿病房住院的早产儿74例随机分为两组,早期干预组37例,观察对照组37例。两组均系统跟踪随访至1周岁,采用CDCC量表进行智力(MDI)及运动能力(PDI)测评,根据0—1岁52项神经运动检查判断脑瘫发生与否。结果:74例早产儿发生脑瘫6例,精神发育迟缓3例。其中干预组发生脑瘫1例,对照组发生脑瘫5例并精神发育迟缓3例。前者两组比较差异无显著性意义(P>0.05),后者两组比较差异有显著性意义(P<0.05)。MDI和PDI评分干预组比对照组分别高11.35分和11.43分,两项两组比较差异有显著性意义(P<0.001,P<0.01)。结论:早期干预对降低脑瘫发生可能有作用,但尚需增大样本进一步观察。
Objective: To observe the effects of early intervention on intelligence, exercise capacity and cerebral palsy in premature infants. Methods: From September 2001 to September 2003, 74 cases of premature infants hospitalized in our newborn ward were randomly divided into two groups: 37 cases in early intervention group and 37 cases in control group. Both groups were systematically followed up to 1 year of age. The scores of MDI and PDI were measured by CDCC scale. The incidence of cerebral palsy was evaluated according to 52 neurological examinations of 0-1 years old. Results: There were 6 cases of cerebral palsy and 3 cases of mental retardation in 74 premature infants. One case of cerebral palsy occurred in intervention group, 5 cases of cerebral palsy in control group and 3 cases of mental retardation. The former two groups had no significant difference (P> 0.05), the latter two groups had significant difference (P <0.05). The scores of MDI and PDI in intervention group were 11.35 and 11.43 higher than those in control group, respectively. There was significant difference between the two groups (P <0.001, P <0.01). Conclusion: Early intervention may play a role in reducing the incidence of cerebral palsy, but we need to enlarge the sample for further observation.