一般认为,P 物质象某些其他神经肽那样是经一种或数种前体大分子翻译后加工而成。采用重组DNA技术,已在牛纹状体鉴别这两种前体,它们是分子量为13,109的α前速激肽原(α-Preprotachykinin)和15,076分子量的β前速激肽原。作者研究了离体背根神经节中P 物质的生物合成表明,从[~(35)S]-甲硫氨酸掺入神经节至其中有标记P 物质出现之间有1～2h 的延搁, It is generally accepted that substance P is, as some other neuropeptides, are processed after translation by one or more precursor macromolecules. Using recombinant DNA technology, these two precursors have been identified in the bovine striatum, which are alpha-preprotachykinin with a molecular weight of 13,109 and beta prekallikrein with a molecular weight of 15,076. The authors studied the biosynthesis of substance P in dorsal root ganglion (DRG) in vitro and showed that there was a 1 ~ 2h delay between the appearance of substance P and the ganglion [~ (35) S] -methionine incorporation,