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目的观察甘精胰岛素在吞咽困难2型糖尿病患者的降糖疗效和安全性。方法选择2型糖尿病患者伴吞咽困难需要鼻饲者77例,随机分组为甘精胰岛素输注观察组39例,胰岛素泵持续皮下输注对照组38例。比较两组患者降糖效果、血糖控制时间、低血糖发生率等方面的差异。结果两组患者治疗后血糖值均显著下降,与治疗前比较有显著性差异(P<0.05);观察组血糖控制时间和低血糖发生率有降低趋势,在血糖控制时间上两组比较有显著性差异(P<0.05)、但在血糖、低血糖发生率方面两组比较无统计学差异(P>0.05)。结论采用甘精胰岛素应用在2型糖尿病伴吞咽困难患者可以快速、有效、安全控制血糖。
Objective To observe the efficacy and safety of insulin glargine in patients with type 2 diabetes who have difficulty in swallowing. Methods 77 type 2 diabetic patients with nasal feeding who needed dysphagia were randomized into insulin glargine observation group (n = 39) and insulin pump (subcutaneous infusion) control group (n = 38). The hypoglycemic effect, blood glucose control time and the incidence of hypoglycemia in the two groups were compared. Results After treatment, the blood glucose levels of both groups decreased significantly (P <0.05), the duration of glycemic control and the incidence of hypoglycemia in the observation group tended to decrease, and there was a significant difference between the two groups in the duration of glycemic control (P <0.05), but there was no significant difference between the two groups in the incidence of blood glucose and hypoglycemia (P> 0.05). Conclusion The use of insulin glargine in type 2 diabetes patients with dysphagia can quickly, effectively and safely control blood sugar.