论文部分内容阅读
目的 研究尼莫地平缓释胶囊在 12名健康受试者中的生物利用度和药代动力学。方法 采用HPLC检测血浆中尼莫地平含量 ,用 3P87软件求药代动力学参数。结果 血浆中尼莫地平回收率大于 90 % ,线性范围为 1.2 5～ 15 0ng·ml-1;单剂量口服缓释胶囊的MRT ,消除和吸收半衰期等均显著大于普通片 (P <0 .0 1) ,AUC为 (94.6± 13.4) % (82 %～ 118% ) ;多剂量口服缓释胶囊和普通片 ,波动系数分别为 (1.6 76± 0 .186 )和 (1.75 1± 0 .15 0 )。结论 尼莫地平缓释胶囊缓释效果明显 ,吸收程度与普通片等效。
Objective To study the bioavailability and pharmacokinetics of nimodipine sustained-release capsules in 12 healthy volunteers. Methods The content of nimodipine in plasma was detected by HPLC, and the pharmacokinetic parameters were determined by 3P87 software. Results The plasma nimodipine recovery was more than 90% with a linear range of 1.2 5 ~ 150 ng · ml-1. The MRT, elimination and half-life of single oral dose sustained release capsules were significantly higher than those of ordinary tablets (P <0. 0 1), and the AUC was (94.6 ± 13.4)% (82% -118%). The multi-dose oral sustained-release capsules and common tablets had a fluctuation coefficient of 1.6 76 ± 0.186 and 1.75 1 ± 0.15 0 ). Conclusion Nimodipine sustained-release capsules have obvious sustained-release effect and the absorption degree is equivalent to common tablets.