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缺氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)是缺氧条件下广泛存在于哺乳动物及人体的一种转录因子。研究证实HIF-1在动物及人体许多肿瘤中大量表达,对肿瘤的生长、血管形成、转移、凋亡及耐药皆有影响。
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor widely present in mammals and humans under hypoxic conditions. Studies have shown that HIF-1 is overexpressed in many tumors in animals and humans and has an impact on tumor growth, angiogenesis, metastasis, apoptosis and drug resistance.