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多伦多市玛格丽公主医院1958～1973年连续治疗109例儿童何杰金氏病。无论期别如何,5年生存率1958～1964年为50%,1965～1968年为73%,1969～1973年为95%。5年内未见复发相应为19%、20%及57%。此种逐步提高疗效来自于相继采用淋巴管造影、剖腹探查及脾切除术、由病变区照射改变为扩大照射野、以及使用多种药物的联合化疗。联合化疗在初期仅用于周身复发,近来则为开始治疗的一部分,对于较晚期儿童,同时併用扩
The Margaret Princess Hospital in Toronto City treated 109 children with Hodgkin’s disease from 1958 to 1973. Regardless of period, the 5-year survival rate was 50% from 1958 to 1964, 73% from 1965 to 1968, and 95% from 1969 to 1973. No recurrence was found in 19 months, 20%, and 57% in 5 years. This gradual improvement in curative effect comes from successive use of lymphangiography, laparotomy and splenectomy, irradiation from the lesion area to expand the irradiation field, and combination chemotherapy using multiple drugs. The combination chemotherapy was used only for the recurrence of the whole body in the early stage, and recently it was part of the start of treatment. For the later children, it is used concurrently.