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巨噬细胞在心肌梗死损伤中发挥了“双刃”作用。近年来研究表明,心肌细胞浸润的巨噬细胞在不同因子刺激下极化成功能不同的亚群,即M1和M2。M1型巨噬细胞主要发挥促炎作用,加重心肌损伤,而M2型巨噬细胞则主要抑制受损组织炎症发生,同时能促进新生血管的生成。因此M2型巨噬细胞在心肌损伤中发挥的正面作用越来越受到关注。本文对近年来国内外关于M2型巨噬细胞在心肌组织中发挥的作用,及其重要调控机制等进行了综述,并对M2型极化在促心肌微血管治疗中的研究现状及其物质基础进行了概述。
Macrophages play a “double-edged” role in myocardial infarction injury. In recent years, studies have shown that myocardial cells infiltrating macrophages polarized under different stimuli to different sub-groups, namely M1 and M2. M1 macrophages mainly play a proinflammatory role, aggravating myocardial injury, while M2 macrophages mainly inhibit the inflammation of impaired tissue, and can promote angiogenesis. Therefore, M2 macrophages play a more and more important role in myocardial injury. In this paper, we reviewed the role played by M2 macrophages in myocardial tissue at home and abroad, and its important regulatory mechanisms. The current research status and the material basis of M2-type hyperemia in myocardial microvascular therapy Outlined.