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目的探讨帕罗西汀辅以心理治疗对结直肠癌患者焦虑及抑郁的疗效。方法采用汉密尔顿抑郁量表(HamiltonDepression Scale,HAMD-24)和汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)对2009年6月-2011年6月住院的200例结直肠癌患者进行评分,调查结直肠癌患者中抑郁焦虑的发生情况。将最终伴抑郁或(和)焦虑的153例患者随机分为对照组、帕罗西汀组、心理治疗组以及帕罗西汀+心理治疗组,以HAMD-24和HAMA评分作为疗效评价指标。结果与非肿瘤住院患者相比,结直肠癌患者中抑郁焦虑的发生率较高(P<0.05),治疗后帕罗西汀组、心理治疗组HAMD-24、HAMA评分比对照组下降更为显著(P<0.05),心理治疗组较帕罗西汀组疗效明显(P<0.05),联合干预组较单独采用帕罗西汀或心理治疗评分下降最为显著(P<0.05)。结论帕罗西汀辅以心理治疗对结直肠癌患者围手术其抗焦虑抑郁效果显著,可提高患者生活质量。
Objective To investigate the effect of paroxetine combined with psychotherapy on anxiety and depression in patients with colorectal cancer. Methods 200 patients with colorectal cancer hospitalized from June 2009 to June 2011 were scored by Hamilton Depression Scale (HAMD-24) and Hamilton Anxiety Scale (HAMA) Depression and anxiety in cancer patients. 153 patients with depression or (or) anxiety finally were randomly divided into control group, paroxetine group, psychotherapy group and paroxetine + psychotherapy group. HAMD-24 and HAMA scores were used as the evaluation index of the curative effect. Results Compared with non-tumor hospitalized patients, the incidence of depression and anxiety was significantly higher in patients with colorectal cancer (P <0.05). After treatment, the scores of HAMD-24 and HAMA in paroxetine group and psychotherapy group were significantly lower than those in control group P <0.05). The effect of psychotherapy group was better than that of paroxetine group (P <0.05). The combination intervention group was more effective than paroxetine alone or psychotherapy score (P <0.05). Conclusion Paroxetine combined with psychological treatment of colorectal cancer patients perioperative anti-anxiety depression effect is significant, can improve the quality of life of patients.