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细胞因子在内毒素引起的肺损伤中具有重要作用,而细胞因子干扰素γ(IFN-γ)在其中的作用尚未深入研究。已知IFN-γ可激活诱导型一氧化氮合酶(iNOS),增高一氧化氮(NO)的水平,而由iNOS产生的大量NO在脂多糖(LPS)引起的急性肺损伤中起着关键作用。本研究旨在探讨IFN-γ在LPS引起的小鼠肺水肿、细胞因子和NO水平的升高及死亡中的作用,并观察了NO对肺水肿和细胞因子释放的影
Cytokines play an important role in endotoxin-induced lung injury, and the role of interferon-gamma (IFN-γ) in them has not been studied further. It is known that IFN- [gamma] activates inducible nitric oxide synthase (iNOS) and increases nitric oxide (NO) levels, whereas a large amount of NO produced by iNOS plays a key role in lipopolysaccharide (LPS) -induced acute lung injury effect. This study aimed to investigate the role of IFN-γin LPS-induced pulmonary edema, cytokine and NO levels and death in mice, and to observe the effect of NO on pulmonary edema and cytokine release