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该研究目的是确定癫痫发作是否与SLE患者血清抗磷脂抗体(aPL)的存在相关。研究对象为到圣·托马斯医院狼疮门诊就诊,符合美国风湿病学会SLE标准的221例连续性、非选择性患者。其中已确定目前或以往癫痫发作除SLE外无其他原因可寻的患者21例。对癫痫出现于SLE任何其他表现之前而接受抗癫痫药物治疗的患者,通过停药后疾病演变的观察来排除药物诱发的狼疮样综合征。根据临床病史及脑电图(EEG)记录诊断癫痫。某些患者在癫痫发作时作了CT和(或)核磁共振成像(MRI)扫描。按照抗癫痫国际协会的分类确定癫痫发作类型。将癫痫组以外的全部SLE患者作为对照。以ELISA检测血清中的抗心磷脂抗
The purpose of this study was to determine if seizures are associated with the presence of serum anti-phospholipid antibodies (aPL) in SLE patients. Subjects were 221 consecutive, nonselective patients who were admitted to St. Thomas Hospital’s lupus clinic and met the criteria of the American College of Rheumatology’s SLE criteria. Among them, 21 cases of patients with seizures who have no other reason than SLE have been identified. Patients with epilepsy treated with antiepileptic drugs prior to any other manifestation of SLE were excluded from drug-induced lupus-like syndrome by observation of the evolution of the disease after discontinuation. Epilepsy was diagnosed based on clinical history and EEG recording. Some patients underwent CT and / or magnetic resonance imaging (MRI) scans at the time of the seizure. The type of epileptic seizure was determined according to the classification of the antiepileptic association. All SLE patients other than the epilepsy group were used as a control. Anti-cardiolipin anti-serum was detected by ELISA