肝细胞癌是严重危害人类生命的一种恶性肿瘤,但其发病机制目前仍未清楚,而临床上大多数患者就诊时已届中晚期,失去了最佳治疗时机,为患者提供治疗的关键是早期诊断,而肿瘤标记物在这方面有其独到的优势,尽管AFP检测在临床上已广泛应用,但还不能完全满足临床要求,所以寻找有助于早期诊断的肿瘤标记物具有很高的临床价值。本文就目前临床上正应用的和近年来新发现的肿瘤标记物综述如下。 Hepatocellular carcinoma is a malignant tumor that seriously endangers human life. However, the pathogenesis of hepatocellular carcinoma is still unclear. Most of the patients in clinical stage have been advanced and have lost the optimal treatment opportunity. The key to providing treatment to patients is Early diagnosis of tumor markers in this area has its unique advantages, although AFP detection has been widely used in clinical practice, but can not fully meet the clinical requirements, so looking for early diagnosis of tumor markers have a high clinical value. In this paper, currently applied in clinical and newly discovered tumor markers in recent years are summarized below.