睡眠-觉醒是一个涉及多系统、多中枢的生理过程,具有复杂的调节机制。近年来,细胞因子在睡眠-觉醒周期中的变化和对睡眠的调节作用已备受关注,其分泌在睡眠过程中表现出一定的昼夜节律性,它们的改变能介导机体内分泌功能的紊乱,使生物体免疫功能降低,导致生理功能受损。提示细胞因子是睡眠的重要调节因子之一。 Sleep - Awakening is a multi-system, multi-central physiological processes, with complex regulatory mechanisms. In recent years, the changes of cytokines in sleep-wake cycle and the regulation of sleep have drawn much attention. Their secretion shows some circadian rhythms during sleep, and their changes can mediate the disturbance of endocrine function, So that organisms reduce immune function, resulting in impaired physiological function. It is suggested that cytokines are one of the important regulators of sleep.