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目的:通过检测稽留流产患者血清皮质醇(Cortisol-COR)与白介素-12(IL-12)的浓度水平,探讨应激、免疫与稽留流产的关系。方法:选取住院部稽留流产患者48例作为试验组,分为清宫前、后两部分;门诊正常早孕妇女48例作为对照组。指导研究对象填写《应激原调查问卷表》,对两组应激原数目进行统计分析。试验组分别于入院第2天及清宫后2周清晨7∶00在安静状态下空腹采取静脉血5 ml,同时对照组于门诊产检时在安静状态下空腹采取静脉血5ml。采用放射免疫和ELISA方法检测两组血清皮质醇、IL-12的含量。结果:试验组清宫前的应激原数目,血清COR浓度高于对照组,差异有统计学意义(P﹤0.05);试验组清宫前IL-12浓度与对照组比较,差异无统计学意义(P﹥0.05);试验组清宫前、后血清COR、IL-12浓度比较,差异无统计学意义(P﹥0.05)。结论:应激、免疫可能同时为稽留流产发病因素,应激在参与稽留流产的形成中,免疫也起一定的作用。
Objective: To investigate the relationship between stress, immunity and missed abortion by detecting serum cortisol-COR and interleukin-12 (IL-12) levels in patients with missed abortion. Methods: Forty-eight patients with missed abortion in inpatient department were selected as the experimental group and divided into two groups. Guide the research object to fill in “stress the original questionnaire”, the two groups of stressors for statistical analysis. In the experimental group, 5 ml of venous blood was taken on the 2nd day of admission and 2 weeks after the Qing Dynasty at 7:00 in the morning, respectively. In the control group, 5 ml of venous blood was taken in the fasted state during the outpatient checkup. The levels of serum cortisol and IL-12 in the two groups were detected by radioimmunoassay and ELISA. Results: Before treatment, the number of stressor and the serum COR concentration in the experimental group were significantly higher than those in the control group (P <0.05). There was no significant difference in IL-12 concentration between the experimental group and the control group P> 0.05). There was no significant difference in serum COR and IL-12 levels between the two groups before and after treatment (P> 0.05). CONCLUSIONS: Stress and immunity may be the cause of missed abortion at the same time. In the formation of stress abortion, stress also plays a role.