论文部分内容阅读
目的:分析CaN信号分子在附子苷治疗心衰过程中的靶向作用。方法:采用SPF级SD大鼠50只用连续腹腔注射盐酸阿霉素的方法复制大鼠心力衰竭模型,待造模成功后将动物分为空白对照组、模型对照组与附子苷治疗组(高、中、低剂量组),用附子苷配制液治疗8天后,用CaN试剂盒检测大鼠血清的CaN的含量。结果:治疗组0.7mg/kg、0.35mg/kg剂量组血清CaN含量均明显高于模型组(P(0.05)。结论:在用附子有效成分—附子苷对心衰进行治疗过程中,CaN信号分子起重要的靶向作用。
Objective: To analyze the role of CaN signaling molecules in the treatment of heart failure with monkshoodin. Methods: Fifty SPF Sprague-Dawley rats were randomly divided into blank control group, model control group and aconitine-treated group (high-dose group) after continuous intraperitoneal injection of doxorubicin hydrochloride , Medium and low dose groups). After treatment with the solution of the aconitine for 8 days, the content of CaN in the serum of the rats was detected by CaN kit. Results: Serum CaN levels in the treatment group (0.7mg / kg, 0.35mg / kg) were significantly higher than those in the untreated group (P <0.05) .Conclusion: CaN signal Molecules play an important role in targeting.