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CD_(38)抗原为分子量45KDa的单链跨膜糖蛋白。过去认为此分子为B淋巴细胞相关抗原,将其作为白血病免疫分型的常用标志之一。我们采用CD_(38)单克隆抗体(McAb)及其它一组CDMcAbs对104例白血病进行检测,以期探讨CD_(38)抗原在白血病细胞上的表达分布及意义。
The CD38 antigen is a single-chain transmembrane glycoprotein with a molecular weight of 45 KDa. In the past, this molecule was considered to be a B-lymphocyte-associated antigen and was used as one of the commonly used markers of leukemia immunophenotyping. We used CD_(38) monoclonal antibody (McAb) and other groups of CDMcAbs to detect 104 cases of leukemia in order to explore the expression and distribution of CD_(38) antigen on leukemia cells.