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目的:观察当归补血汤中当归与黄芪的不同配比对黄芪甲苷、阿魏酸及芒柄花素含量的影响。方法:将当归补血汤进行5种当归与黄芪的不同配比(1∶1、1∶2、1∶5、1∶7、1∶10),通过高效液相色谱法对黄芪甲苷、阿魏酸以及芒柄花素分别进行线性关系、精密度、重复性及回收率检测。结果:对照样品线性关系良好,精密度、重复性及回收率均满足标准;随着黄芪配比上升,黄芪甲苷、阿魏酸、芒柄花素含量上升,至1∶5(当归∶黄芪)时达最高值,后逐渐降低。结论:当当归补血汤内当归与黄芪配比为1∶5时,黄芪甲苷、阿魏酸及芒柄花素的含量最高,可保证配方药效充分发挥,需引起临床重视。
OBJECTIVE: To observe the effect of different proportion of Angelica sinensis and Radix Astragali on the contents of Astragaloside Ⅳ, ferulic acid and formononetin in Dangguibuxuetang. Methods: Dangguibuxuetang 5 different ratios of Angelica and Astragalus (1: 1, 1: 2, 1: 5, 1: 7, 1:10), by high performance liquid chromatography on Astragaloside, A Weic acid and the formononetine were linear relationship, precision, repeatability and recovery test. Results: The linearity of the control sample was good, and the precision, repeatability and recovery rate all met the standard. With the increase of astragalus ratio, the content of astragaloside, ferulic acid and formononetin increased to 1: 5 ) Reached the highest value, then gradually decreased. Conclusion: Danggui Buxue Tang Angelica and Astragalus ratio of 1: 5, the highest content of Astragaloside, ferulic acid and formononetin, to ensure the full formulation efficacy, the need for clinical attention.